By 1953, scientists knew much about DNA, including its chemical components and how they related to each other. There was even X-ray crystallography of the molecule. However, the structure of DNA in three-dimensional space remained a mystery. James Watson and Francis Crick experimented with building wooden models, creating several until they found the one that fit all of what was already known. This work, which relied heavily on the use of physical models, earned them and their colleague, Maurice Wilkins, a Nobel Prize. Their discovery of the physical structure of the DNA molecule was a breakthrough that lead to massive advances in the understanding of genetics and in medicine.
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